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Is a skin biopsy painful?
The local anaesthetic injection causes a brief stinging sensation, after which the biopsy site is completely numb and the procedure is painless. Some mild tenderness around the biopsy site is normal in the days following, which resolves quickly and is managed with standard over-the-counter pain relief.
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What are the different types of skin biopsy?
A punch biopsy removes a small cylindrical core of full-thickness skin using a circular cutting tool — ideal for inflammatory conditions and pigmented lesions. A shave biopsy removes a superficial sample using a blade — suitable for raised, benign-appearing lesions. An incisional biopsy samples a portion of a larger lesion. An excisional biopsy removes the entire lesion with a margin — combining diagnosis and treatment.
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How long does it take to get biopsy results?
Results are typically available within 7–14 working days from the date of the biopsy. If the laboratory requires additional specialist stains or second-opinion reporting, this may extend the timeline slightly. Your clinician will inform you if any delay is expected. Results are never communicated by letter alone — a follow-up appointment is always arranged.
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Will I have a scar?
All skin biopsies leave a small scar. The size depends on the biopsy technique and the size of the sample taken. Punch and shave biopsies typically produce very small, inconspicuous marks. Excisional biopsies leave a linear scar that fades over 12 months. Your clinician will place the biopsy site to minimise scar visibility wherever possible.
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Can a biopsy miss the diagnosis?
Sampling error — where the biopsy does not capture representative tissue — is occasionally possible, particularly with large or heterogeneous lesions. Your consultant dermatologist selects the most informative site for biopsy to minimise this risk. If the histology result does not correlate with the clinical picture, repeat biopsy or further investigation may be recommended.
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What conditions are commonly diagnosed by skin biopsy?
Skin biopsy is used to diagnose inflammatory conditions such as psoriasis, lichen planus, lupus, and dermatitis; bullous (blistering) diseases; pigmented lesions including atypical naevi and melanoma; suspected skin cancers including BCC, SCC, and lymphoma; and unusual or persistent rashes that have not responded to empirical treatment.
Your Patient Journey
1. Your
Consultation
Your clinician will explain why a biopsy is being recommended, what type of biopsy will be performed, and what the results may indicate. The risks of the procedure are discussed and consent is obtained. The target lesion is examined and the procedure is planned, including the choice of technique and the expected scar.